ABSTRACT
Neurofi broma is a benign peripheral nerve sheath tumor and one of the most frequent tumors of neural origin. Its presence is one of the main clinical criteria for the diagnosis of neurofi bromatosis Type I (NF-I). NF-I is a hereditary disorder inherited as an autosomal dominant trait and the patients present with skin lesions, i.e., café au lait spots and neurofi bromas. Diagnosis is mainly based on a series of clinical criteria. NF-I may present with defi nite oral lesions, which mandate the dental surgeons with the responsibility of accurate diagnosis. Th e paper emphasizes the role of an oral diagnostician in the recognition of NF-I in a family.
ABSTRACT
Two antifilarial compounds, viz., 90/55 (7-oxo-1-phenyl-8, 14-dihydropyrido (3,4-b) imidazo (1,2-c) quinazolo (4,5-g) and 87/639 (6-Nitro-1-phenyl-9H-pyrido (3,4-b) indole at 0.5 and 2.0 micron concentrations substantially inhibited glucose uptake and increased lactate production by L. carinii during in vitro incubation for 2 hr. The treated parasites, showed increased activities of glycogen phosphorylase, phosphofructokinase and pyruvate kinase. Hexokinase and fumarate reductase activities level in the worms were significantly lowered. Therefore it appears that both the compounds kill adult L. carinii by interfering with its carbohydrate metabolism.
Subject(s)
Animals , Anthelmintics/pharmacology , Carbohydrate Metabolism , Carbolines/pharmacology , Female , Filarioidea/drug effectsABSTRACT
A study of knowledge, attitude and practice of leprosy among doctors of Bhopal has found that junior doctors had more exposure to leprology compared to all other groups. Medical college doctors had better knowledge of leprology compared to non-medical college doctors. Knowledge and attitude about leprosy among doctors were influenced by qualification, age, cultural and environmental factors. A strong association was observed between knowledge and attitude about leprosy of doctors and their practice of treating leprosy cases.